Curative and Preventive Properties of Medicinal Plants

Research on Disease Management and Animal Model Studies
Megh R. Goyal, Junaid Ahmad Malik, Ademola Olabode Ayeleso

ISBN: 9781774911952
Publisher/Imprint: AAP, CRC Press (Taylor & Francis Group)
Pages: 419
Format: Print/e-Book
Language: English
Edition/Volume: 1st
© Year: 2023
Publication date: April 2023



About the Book

Animal models varying from mammals to flies and worms are widely used in studying human diseases. These models share homolog genes as expressed in a human disease condition, helping to elucidate mechanisms and pathways of these diseases in different organs of the animals, which might be difficult in clinical-based research. This book provides scientific reports on therapeutic potentials of medicinal plants in different animal models and provides information on the beneficial roles of the medicinal plants on human diseases.

The chapters look at number of different medicinal plants and several different animal models, examining the medicinal properties and activities of the plants for a variety of health issues, such as for diabetes, cardiovascular disease, neurodegenerative disease, organ dysfunctions, cancer, for labor and postpartum issues, and more. The therapeutic mechanisms of some phytoconstituents are also discussed.

This important compendium provides valuable information for researchers and scientists involved in drug delivery and development, pharmacognosy, pharmacology, and biochemistry.

Table of Contents




1. Leaf Extract of Dombeya buettneri for Inhibition of Inflammatory Cytokines Aggregation in Type-2 Diabetes
Esther Emem Nwanna, Olusola Olalekan Elekofehinti, Festus Igbe, and Adebola Oluwayemisi Ayeni

2. Antidiabetic Potential of African Medicinal Plants: A Brief Review Using Animal Models
Gbolahan Iyiola Asejeje and Folake Olubukola Asejeje

3. In vitro Antioxidant and Nephroprotective Activities of Carica papaya Methanol Extracts Using Streptozotocin-Induced Diabetic Male Albino Rats
Modupe Olusola Adetayo, Oluwaseyi Adegoke Adetunji, Babafemi Tosin Ogunbiyi, Gogonte Hezekiah Amah, Omowunmi O. Akinnawo, Laide O. Olajide, and Toyosi S. Ajiboye

4. Potential of Moringa oleifera for Prevention of Cardiovascular Diseases in Animal Models
Olufemi Idowu Oluranti

5. Blood Sugar Regulation and Pro-Inflammatory Effects of Desplatsia dewevrei in Streptozotocin-Induced Diabetic Wistar Rats
Oghale O. Godwin and MacDonald Idu


6. Plant-Based Antioxidants in the Prevention and Treatment of Neurodegenerative Diseases: Pros and Cons
Folake Olubukola Asejeje and Gbolahan Iyiola Asejeje

7. Neuroprotective Efficacy of Ethnomedicinal Plants in Mental Disorders with Animal Models
Adedamola Aminat Bayo-Olugbami, Joseph Enya, and Olorunfemi Samuel Tokunbo

8. Translational Neuroprotective Activity of Curcumin in Neurodegenerative Diseases: An Overview with Animal Models
Adedamola Aminat Bayo-Olugbami, Kawkab Mujahidah Babalola, and Aminat Omolola Imam-Fulani


9. Multiple Organ Dysfunction Syndrome: Phytotherapeutic Evidence from Intestinal Ischemia-Reperfusion Models
Akinleye Stephen Akinrinde and Joseph Fadeyemi Akinrinmade

10. Biochemical Constituents and Toxicological Effects of Syzygium aromaticum on Selected Organs in Male Wistar Rats
Mosebolatan Victoria Adegbola, Ademola Olabode Ayeleso, and Temitope Adenike Oyedepo

11. Therapeutic Mechanisms of Bioactive Compounds in Lipopolysaccharide-Induced Liver Injury with Murine Models
Ayokanmi Ore, Ebenezer Tunde Olayinka, Babajide Oluwaseun Ajayi, and Oluseyi Adeboye Akinloye

12. Telfairia occidentalis for the Alteration of Expression Ratio of Bax/Bcl-2 mRNA in Lead-Exposed Rat Testicular Tissues
Adefolaju Gbenga Anthony, Falana Benedict Abiola, Odukoya Samson Ayodeji, and Mwakikunga Anthony


13. Hydro-Ethanolic Leaf Extract of Parquetina nigrescens: Hematological Indices and Biochemical Parameters in Male Wistar Rats
Lydia Oluwatoyin Ajayi, Ademola Olabode Ayeleso, and Temitope Adenike Oyedepo

14. Role of Phytochemicals in Allium sativum on Obesity: A Review
Ayodeji Emmanuel Adepoju, Gregory Joseph, Samuel Olufolarin Babarinde, and Ademola Olabode Ayeleso

15. Antidiabetic Potency of Tofu (Soybean Meal)
Modupe Olusola Adetayo, Maria Onomaghuan Ebesunun, Olugbenga Obajimi Adebawo, Adekunle Moses Adetayo, Ifeoluwa Opeyemi Alao-Owunna, and Samuel Adegoke Adewole

16. Antioxidant Potential of Seed and Leaf Extracts of Adansonia digitata
Adetoun Elizabeth Morakinyo, Samuel Chibueze Nzekwe, Samuel Olufolarin Babarinde, Oluwatosin Elijah Olopade, Abraham Yakubu, and Ifeoluwa Dorcas Adegbite

17. Antioxidant, Anti-inflammatory, and Thrombolytic Activities of Monodora tenuifolia, Benth Seed Extract
Ademola Olabode Ayeleso, Olagunju Doris Imuetiyanosa, Samuel Chibueze Nzekwe, and Oluokun Oluboade Oyedapo

18. Effects of Taraxacum officinale Extract on Hematological Parameters in Female Wistar Rats with Ethanol-Induced Toxicity
Ademola Olabode Ayeleso, Samuel Chibueze Nzekwe, Favour Oghenefejiro, Samuel Olufolarin Babarinde, and Ayodeji Emmanuel Adepoju

19. Antimutagenic Activity of Moringa oleifera Seeds
Temitope Abiola, Olakunle Akinyode, Bisola Jimoh, Babawale Emmanuel Abiola, Ibukun Temitope Sossou, Adedayo Olukanni, and Olumide Olukanni

20. Scope of Medicinal Plants for Uterotonic, Tocolytic, and Wellness Effects in Pregnant Women: A Cultural Perspective
Hertha Kasiku Haikera, Larai Aku-Akai, and Yapo Guillaume Aboua

21. Role of Phytonutrients in Chemoprevention of Cancer: A Review
Oluwaseyi Adegoke Adetunji, Modupe Olusola Adetayo, Babafemi Tosin Ogunbiyi and Gogonte Hezekiah Amah


About the Authors/Editors

Megh R. Goyal, PhD
Retired Professor in Agricultural and Biomedical Engineering, University of Puerto Rico, Mayaguez Campus; Senior Acquisitions Editor, Biomedical Engineering and Agricultural Science, Apple Academic Press, Inc.

Megh R. Goyal, PhD, PE, is a Retired Professor in Agricultural and Biomedical Engineering from the General Engineering Department in the College of Engineering at the University of Puerto Rico–Mayaguez Campus. He has worked as a Soil Conservation Inspector and as a Research Assistant at Haryana Agricultural University and Ohio State University. He was the first agricultural engineer to receive the professional license in Agricultural Engineering from the College of Engineers and Surveyors of Puerto Rico and was proclaimed as the “Father of Irrigation Engineering in Puerto Rico for the twentieth century” by the ASABE, Puerto Rico Section, for his pioneering work on micro irrigation, evapotranspiration, agroclimatology, and soil and water engineering. During his professional career of over 52 years, he has received many prestigious awards. A prolific author and editor, he has written more than 200 journal articles and several textbooks and has edited over 100 books.

Junaid Ahmad Malik, PhD
Lecturer, Department of Zoology, Government Degree College, Bijbehara, Kashmir (J&K), India

Junaid Ahmad Malik, PhD, is a Lecturer with the Department of Zoology at Government Degree College, Bijbehara, Kashmir (J&K), India, and is actively involved with teaching and research activities. He has more than eight years of research experience. His areas of interest are ecology, soil macrofauna, wildlife biology, conservation biology, etc. Dr. Malik has published 21 research articles and technical papers in international peer-reviewed journals and has authored and edited books, book chapters, and more than 10 popular editorial articles. He also serves as an editor and reviewer of several journals. He has participated in several state, national, and international conferences, seminars, workshops, and symposia and has more than 20 conference papers to his credit. He is a life member of the Society for Bioinformatics and Biological Sciences.

Ademola Olabode Ayeleso, PhD
Associate Professor of Biochemistry, Adeleke University, Ede, Nigeria

Ademola Olabode Ayeleso, PhD, is Associate Professor of Biochemistry at Adeleke University, Ede, Nigeria. He is presently the Ag. Director of the Office of Research, Grants and Linkages (ORGL) and the Chairman of the University Ethical Research Committee at Adeleke University.He was appointed as a member of the Adeleke University 2020–2025 strategic plan drafting committee to appraise all research and academic activities of the university in 2019. He has recently established a research group named DrosophilaAU Research Group at Adeleke University, Nigeria, in which fruit flies (Drosophila Melanogaster) are being used as a model to study diabetes and obesity. He has also worked as a Postdoctoral Research Fellow at three different universities in South Africa. Dr. Ayeleso is actively involved in life science research, especially in the niche of diabetes/obesity and herbal medicine. He has vast experience teaching different courses in biochemistry at both the undergraduate and postgraduate levels. Dr. Ayeleso is a prolific writer with over 30 publications to his credit and has attended several national and international scientific conferences. He is also a member of several professional bodies and an alumnus of Nobel laureates meeting in medicine/ physiology held in Germany in 2011.

Dr. Ayeleso earned his doctoral degree in Biomedical Technology at the Department of Biomedical Sciences, Cape Peninsula University of Technology (CPUT), Bellville, in 2013, South Africa. Dr. Ayeleso was awarded a Master of Science degree in Biochemistry from the University of Port Harcourt, Port Harcourt, Nigeria, in 2007 and Bachelor of Technology degree in Biochemistry from the Federal University of Technology, Akure, Nigeria in 2002.

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